|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We further investigated the distribution of rs</span>12255372 and rs7903146 genotypes according gastric cancer stratified by degree of differentiation, and we observed that carriers of rs7903146 T allele (CT + TT vs CC) had a significantly increased risk of moderate/well differentiated gastric cancer (dominant model, OR = 2.55, 95%CI: 1.35-4.80, P = 0.004), whereas the rs7903146 TT genotype was associated with poorly differentiated gastric cancer in the recessive model (OR = 3.65, 95%CI: 1.25-10.62, P = 0.018).
|
27605886 |
2016 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigated associations between rs12255372 and prostate cancer risk among 1,457 cases and 1,351 controls from a population-based study.
|
18302196 |
2008 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer.
|
28949031 |
2018 |
|
Premature adrenarche
|
|
0.010 |
GeneticVariation
|
BEFREE |
The differences in the minor allele frequencies (MAFs) of rs9939609, rs7903146, and rs12255372 were not statistically significant between the PA and control groups (difference in MAFs [95% confidence interval]: -0.06 [-0.18, 0.05], 0.04 [-0.05, 0.12], and 0.01 [-0.07, 0.10]; P = .3, .4, and .8, respectively).
|
19497595 |
2009 |
|
Polycystic Ovary Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
Association between rs7903146 and rs12255372 polymorphisms of transcription factor 7-like 2 gene and polycystic ovary syndrome: a systematic review and meta-analysis.
|
25678248 |
2015 |
|
Polycystic Ovary Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
Minor allele frequencies (MAFs) of rs4506565 (P=0.61), rs7903146 (P=0.68), rs12243326 (P=0.56), and rs12255372 (P=0.60) were comparable between PCOS cases and control subjects.
|
24157263 |
2014 |
|
Polycystic Ovary Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
Four-locus (rs4506565-rs7903146, rs12243326, and rs12255372) haplotype analysis identified PCOS-susceptible (ACTG) and -protective (TTTG) haplotypes, which remained significant after controlling for multiple comparisons and for key covariates.
|
26536002 |
2015 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
TCF7L2 rs12255372 polymorphism protects Mexican children from obesity.
|
22136959 |
2011 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped the TCF7L2 single nucleotide polymorphisms rs7903146 and rs12255372 (previously associated with type 2 diabetes) and rs10885406 and rs7924080 (which tag haplotype A [HapA], a haplotype reported to be associated with obesity) in 2,512 FHS participants.
|
19183934 |
2009 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated the effect of single nucleotide polymorphisms (SNP), rs7903146 and rs12255372, within the TCF7L2 locus on postprandial lipemia and other MetS-related traits and their modulation by dietary fat.
|
19141698 |
2009 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS.
|
29971604 |
2018 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
The two markers located within the TCF7L2 gene showed strong associations with T2D (rs7903146, T allele, odd ratio (OR) = 1.76, p = 0.001 and rs12255372, T allele, OR = 1.78, p = 0.002), but did not show significant association with MS.
|
20503258 |
2010 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
We further investigated the distribution of rs</span>12255372 and rs7903146 genotypes according gastric cancer stratified by degree of differentiation, and we observed that carriers of rs7903146 T allele (CT + TT vs CC) had a significantly increased risk of moderate/well differentiated gastric cancer (dominant model, OR = 2.55, 95%CI: 1.35-4.80, P = 0.004), whereas the rs7903146 TT genotype was associated with poorly differentiated gastric cancer in the recessive model (OR = 3.65, 95%CI: 1.25-10.62, P = 0.018).
|
27605886 |
2016 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigated associations between rs12255372 and prostate cancer risk among 1,457 cases and 1,351 controls from a population-based study.
|
18302196 |
2008 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer.
|
28949031 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation
|
BEFREE |
Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer.
|
28949031 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation
|
BEFREE |
We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).
|
31485167 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results demonstrate that patients with the T/T genotype for the rs12255372 polymorphism of the TCF7L2 gene present an increased colorectal cancer risk (OR=2.64, P=0.0236).
|
27755946 |
2016 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Studies on the association between the TCF7L2 rs12255372 polymorphism and breast cancer risk have reported conflicting results.
|
24266846 |
2013 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer.
|
28949031 |
2018 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Specifically, the same risk allele of single nucleotide polymorphism (SNP) rs12255372 that is associated with diabetes (T allele) has recently been associated with an increased risk of breast cancer.
|
18302196 |
2008 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that TCF7L2 gene polymorphisms (rs12255372 and rs7903146) are associated with an increased susceptibility to brea</span>st cancer.
|
25867435 |
2015 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters.
|
21301999 |
2012 |
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glucose intolerance in Japanese-Brazilians.
|
21399856 |
2011 |
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined whether the two most strongly associated variants (rs12255372 and rs7903146) predict the progression to diabetes in persons with impaired glucose tolerance who were enrolled in the Diabetes Prevention Program, in which lifestyle intervention or treatment with metformin was compared with placebo.
|
16855264 |
2006 |